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Abstract
Eighty-five patients with squamous cell carcinoma of the oropharynx were studied to
assess the value of histopathologic parameters related to their survival. The overall
survival was 58 percent at 3 years and 51 percent at 5 years. Stepwise logistic regression
analysis was used to determine the prognostic value of each of the histopathologic
features. The extent of in situ carcinoma and presence of multifocality were positive
predictors of survival, and perineural invasion and nodal involvement on clinical
examination were negative predictors. None of the other parameters used in this study
attained statistical significance. We conclude that the histologic grade traditionally
used to predict clinical behavior may not be useful. Clinical stage, particularly
nodal status; perineural invasion; and the multifocal or in situ disease, should be
considered in pathologic reports to provide better prognostic profile in oropharyngeal
carcinoma.
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© 1989 Published by Elsevier Inc.
