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Abstract
This study evaluates the penetration of cephalosporins into the peritoneal fluid.
Forty-six patients scheduled for abdominal surgery were randomized into three groups.
On call to the operating room each patient was given a single 1 g dose of cefazolin,
cefuroxime, or ceftazidime. Samples of the peritoneal fluid and blood were simultaneously
obtained immediately after opening the peritoneal cavity. The mean serum cefazolin
concentration was the highest. High peritoneal fluid levels of all three antibiotics
were found; however, the antibacterial activity against common intestinal pathogens
varied significantly. Cefazolin is the only study drug that-possesses marginal in
vitro activity against Streptococcus faecalis, a species generally considered resistent
to cephalosporins. This study suggests that prophylactic second and third generation
cephalosporins are not superior to cefazolin.
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© 1989 Published by Elsevier Inc.
