This paper is only available as a PDF. To read, Please Download here.
Abstract
The unsolved problem of valvular incompetence is a common denominator to chronic venous
insufficiency. Cardiac experience with tissue valves suggests the potential for their
use in more peripheral locations. The current initial work evaluated 22 valvular xenografts
placed in the inferior vena cavas of 22 dogs. Patency extended to 28 months in 12
valves. There was a plausible explanation for failure in 8 of the 10 unsuccessful
units. Patent valves functioned with minimal pressure gradients at moderate flow with
no evidence of pulmonary emboli. Retrograde valvulograms showed acceptable functional
competence in six of eight units examined despite autopsy evidence of leaflet fibrosis
and anatomic incompetence. The study establishes the feasibility of long-term patency
of valvular xenografts in the inferior vena cava, but also raises questions concerning
design requirements for prosthetic venous valves.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The American Journal of SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- A rational approach to surgery of the chronic venous stasis syndrome.Ann Surg. 1982; 195: 25-29
- An experimental and clinical evaluation of grafts in the venous system.Surg Gynecol Obstet. 1970; 139: 1172-1186
- Venous prosthetic valves: The first step toward an investigation in the canine model.Invest Radiol. 1985; 20: 42-44
- Development of a prosthetic venous valve.J Biomed Mater Res. 1985; 19: 827-832
- Femoral vein valve incompetence: Treatment with a xenograft monocusp patch.J Vasc Surg. 1986; 3: 932-935
- On permanent patency of the mouth of the aorta, or inadequacy of the aortic valves.Edinburgh Med Surg J. 1832; 37: 225
- Dynamics of the circulation in aortic valvular disease.Am J Med. 1955; 18: 855-870
- Effect of heart rate on aortic insufficiency as measured by a dye-dilution technique.Circulation. 1961; 9: 413-417
- Combined flowmeter-dye dilution study of the acute effects of changes in heart rate by vagal stimulation on the degree of experimental aortic regurgitation.Physiologist. 1961; 4: 70
- Quantitative hemodynamic effects of heart rate in aortic regurgitation.Circulation. 1971; 44: 355-367
- Direct determinations of aortic blood flow in patients with aortic regurgitation.Circulation. 1967; 35: 32-45
Article info
Footnotes
☆Supported in part by a grant from Shiley, Inc., Irvine, California.
Identification
Copyright
© 1989 Published by Elsevier Inc.
