Advertisement

Treatment and outcome of patients with intracystic papillary carcinoma of the breast

      Abstract

      Background:

      Intracystic papillary carcinoma (IPC) of the breast is a rare form of noninvasive breast cancer. An appreciation of associated pathology with IPC may be critical in surgical decision-making.

      Methods

      The medical records of all patients with IPC treated between 1985 and 2001 were retrospectively reviewed. Three patient groups were identified according to the pathologic features of the primary tumor: IPC alone, IPC with associated ductal carcinoma in situ (DCIS), and IPC with associated invasion with or without DCIS. Types of treatment and outcomes were compared between groups.

      Results:

      Forty patients were treated for IPC during the study period. Fourteen had pure IPC, 13 had IPC with DCIS, and 13 had IPC with invasion. The incidence of recurrence and the likelihood of dying of IPC did not differ between the three groups regardless of the type of surgery (mastectomy or segmental mastectomy) performed and whether radiation therapy was administered. The disease-specific survival rate was 100%.

      Conclusions

      When IPC is identified, it is frequently associated with DCIS and or invasion. Standard therapy should be based on associated pathology. The role of radiation therapy in pure IPC remains to be determined.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Carter D.
        • Orr S.L.
        • Merino M.J.
        Intracystic papillary carcinoma of the breast. After mastectomy, radiotherapy or excisional biopsy alone.
        Cancer. 1983; 52: 14-19
        • Czernobilsky B.
        Intracystic carcinoma of the female breast.
        Surg Gynecol Obstet. 1967; 124: 93-98
        • Gatchell F.G.
        • Dockerty M.B.
        • Clagett O.T.
        Intracystic carcinoma of the breast.
        Surg Gynecol Obstet. 1958; 106: 347-352
      1. Rosen P.P. Oberman H.A. Rosai J. Tumors of the mammary gland. 3rd ed. Armed Forces Institute of Pathology, Washington, DC1992: 209-219
        • Kraus F.T.
        • Neubecker R.D.
        The differential diagnosis of papillary tumors of the breast.
        Cancer. 1962; 29: 1097-1104
        • Squires J.E.
        • Betsill W.L.J.
        Intracystic carcinoma of the breast.
        Acta Cytol. 1981; 25: 267-271
      2. Tumors of the breast.
        in: McDivitt R.W. Stewart F.W. Berg J.W. Atlas of tumor pathology. Armed Forces Institute of Pathology, Washington, DC1969: 1-22 (2nd series, fascile 2)
        • Papotti M.
        • Eusebi V.
        • Gugliotta P.
        • et al.
        Immunohistochemical analysis of benign and malignant papillary lesions of the breast.
        Am J Surg Pathol. 1983; 7: 451-461
        • Lefkowitz M.
        • Lefkowitz W.
        • Wargotz E.S.
        Intraductal (intracystic) papillary carcinoma of the breast and its variants.
        Hum Pathol. 1994; 25: 802-809
        • Leal C.
        • Costa I.
        • Fonseca D.
        • et al.
        Intracystic (encysted) papillary carcinoma of the breast.
        Hum Pathol. 1998; 29: 1097-1104
        • Harris K.P.
        • Faliakou E.C.
        • Exon D.J.
        • et al.
        Treatment and outcome of intracystic papillary carcinoma of the breast.
        Br J Surg. 1999; 86: 1274-1275
        • Jeffrey P.B.
        • Ljung B.M.
        Benign and malignant papillary lesions of the breast. A cytomorphologic study.
        Am J Clin Pathol. 1994; 101: 500-507
        • Leiberman L.
        • Bracero N.
        • Vuolo M.A.
        • et al.
        Percutaneous large-core biopsy of papillary breast lesions.
        AJR Am J Roentgenol. 1999; 172: 331-337