Abstract
Background
A new intracellular adenosine triphosphate (ATP) delivery technique has been developed
and was tested for skin wound care.
Methods
Eleven pairs of adult nude mice were used. ATP-vesicles were applied in 11 mice, and
another 11 mice were treated with lipid vesicles only.
Results
The group treated with ATP-encapsulated fusogenic small, unilamellar lipid vesicles
healed faster than the group treated with only lipid vesicles. Histologic study indicated
better developed granular tissue and re-epithelialization in the study group, and
wound tissue vascular endothelial growth factor expressions were also higher in ATP-vesicles
treated mice.
Conclusions
This intracellular ATP delivery system may provide a new hope for wound healing as
well as the treatment of medical conditions in which ischemia is involved.
Keywords
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Article info
Publication history
Received in revised form:
July 28,
2006
Received:
April 27,
2006
Identification
Copyright
© 2007 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Erratum: Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphateThe American Journal of SurgeryVol. 195Issue 1
- PreviewIn the article “Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate” by B. Chiang, et al (Am J Surg 2007;193:213–218), in Figure 5 the comparison of VEGF expressions was made between ATP-vesicles and normal saline. Normal saline was used in the control group, not vesicles.
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