Abstract
Background
Oncotype DX is a 21-gene assay that calculates a risk of distant recurrence in women with
estrogen-receptor–positive, lymph node–negative breast cancer. The purpose of this
study was to determine whether the results of Oncotype DX influence the decision to administer chemotherapy.
Methods
A retrospective study was performed on 85 consecutive patients with estrogen-receptor–positive,
lymph node–negative breast cancer who had an Oncotype DX recurrence score (RS) obtained. Tumor size, tumor grade, and treatment were then
compared within each risk category. Statistical analysis was performed using STATA
software.
Results
Tumors that were high grade and Her-2/neu positive more frequently had a high RS.
Treatment was changed as a result of Oncotype DX in 44% of patients.
Conclusions
Oncotype DX RS is significantly related to tumor grade and Her2/neu status. In this study,
the treatment of 44% of patients was altered as a consequence of Oncotype DX RS.
Keywords
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References
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Erb C, Fox KR, Patel M, et al. Evaluation of practice patterns in the treatment of node-negative, hormone-receptor positive breast cancer patients with the use of the Oncotype DX assay at the University of Pennsylvania. Abstract [no. 3082] presented at The 2007 San Antonio Breast Cancer Symposium, San Antonio, TX, December 13 to 16, 2007.
Article info
Publication history
Received in revised form:
June 3,
2008
Received:
April 16,
2008
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
