Abstract
Background
In women undergoing breast conserving surgery (BCS), up to 60% can require re-excision.
Our objective is to develop an optically based technology which can differentiate
benign from malignant breast tissues intraoperatively through differences in tissue
composition factors.
Methods
A prospective study of optical imaging of BCS margins is being performed. Optical
images are transformed into tissue composition maps with parameters of total hemoglobin
concentration, b-carotene concentration and scattering. The predicted outcome is then
compared to the margin-level pathology.
Results
Fifty-five margins from 48 patients have undergone assessment. Within 34 specimens
with pathologically confirmed positive margins, the ratio map of b-carotene/scattering
showed the most significant difference reflecting a decrease in adipose and an increase
in cell density within malignant margins (p=.002). These differences were notable
in both in-situ and invasive disease.
Conclusions
We present a novel optical spectral imaging device that provides a rapid, non-destructive
assay of the tissue composition of breast tumor margins.
Keywords
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Article info
Publication history
Received in revised form:
June 30,
2009
Received:
March 24,
2009
Identification
Copyright
© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
