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Prognostic factors after liver resection for hepatocellular carcinoma: a single-center experience from China

  • Liguo Liu
    Affiliations
    Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-fu-yuan 1, Wang-fu-jing, Beijing, 100730, China

    Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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  • Ruoyu Miao
    Affiliations
    Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-fu-yuan 1, Wang-fu-jing, Beijing, 100730, China
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  • Huayu Yang
    Affiliations
    Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-fu-yuan 1, Wang-fu-jing, Beijing, 100730, China
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  • Xin Lu
    Affiliations
    Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-fu-yuan 1, Wang-fu-jing, Beijing, 100730, China
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  • Yi Zhao
    Affiliations
    Bioinformatics Research Group, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China
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  • Yilei Mao
    Affiliations
    Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-fu-yuan 1, Wang-fu-jing, Beijing, 100730, China
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  • Shouxian Zhong
    Affiliations
    Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-fu-yuan 1, Wang-fu-jing, Beijing, 100730, China
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  • Jiefu Huang
    Affiliations
    Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-fu-yuan 1, Wang-fu-jing, Beijing, 100730, China
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  • Xinting Sang
    Affiliations
    Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-fu-yuan 1, Wang-fu-jing, Beijing, 100730, China
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  • Haitao Zhao
    Correspondence
    Corresponding author: Tel.: +86-10-65296042; fax: +86-10-65296043
    Affiliations
    Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-fu-yuan 1, Wang-fu-jing, Beijing, 100730, China
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Published:December 19, 2011DOI:https://doi.org/10.1016/j.amjsurg.2011.05.010

      Abstract

      Background

      This study aimed to clarify the risk factors for survival and recurrence of hepatocellular carcinoma (HCC) in a cohort of Chinese HCC patients after hepatectomy and to compare 6 developed staging systems.

      Methods

      A retrospective analysis was performed on 165 consecutive patients. The Kaplan–Meier method was used to calculate survival. Postoperative prognostic factors were evaluated using univariate and multivariate analyses. The overall predictive power of each staging system was evaluated by the area under the receiver operating characteristic curve.

      Results

      The overall survival rates of 1, 3, and 5 years were 81.2%, 58.6%, and 56.7%, respectively, and the corresponding disease-free survival rates were 52.9%, 23.3%, and 15.5%, respectively. α-fetoprotein level and blood transfusion were correlated significantly with patients' overall survival, and portal vein thrombosis and tumor size (>5 cm) were correlated significantly with poor disease-free survival.

      Conclusions

      The French staging system is better for predicting the prognosis of HCC patients receiving surgical treatment.

      Keywords

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