Abstract
Background
Premenopausal women represent approximately 35% of new breast cancer diagnoses. Diagnosis
and treatment may lead to substantial disruption in quality of life (QOL).
Methods
Premenopausal patients (aged 18 to 50 years) treated for nonmetastatic breast cancer
completed a mailed questionnaire. Multiple self-reported QOL measures and clinical
data were collected. Cluster analysis and Cronbach's α were used to validate the survey.
Analysis of variance was performed for specific interventions. Lower interference
scores conveyed higher QOL.
Results
The response rate was 49.8%. Cronbach's α was 0.96. Immediate contralateral prophylactic
mastectomy (CPM) carried the highest interference (mean, 3.3148) with sexuality compared
with no CPM (mean, 2.85) or delayed CPM (P = .03). Breast conservation had the least interference with appearance (P < .01) and work and finances (P = .02).
Conclusions
Therapeutic mastectomy and CPM with or without reconstruction may adversely affect
QOL. These findings suggest that the choice and timing of interventions may significantly
affect patient satisfaction.
Keywords
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Article Info
Publication History
Published online: September 09, 2013
Received in revised form:
August 6,
2013
Received:
May 21,
2013
Footnotes
This study was supported by the Pain and Palliative Care Department at Moffitt Cancer Center (Tampa, FL).
The authors declare no conflicts of interest.
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
