Abstract
Background
Premenopausal women represent approximately 35% of new breast cancer diagnoses. Diagnosis
and treatment may lead to substantial disruption in quality of life (QOL).
Methods
Premenopausal patients (aged 18 to 50 years) treated for nonmetastatic breast cancer
completed a mailed questionnaire. Multiple self-reported QOL measures and clinical
data were collected. Cluster analysis and Cronbach's α were used to validate the survey.
Analysis of variance was performed for specific interventions. Lower interference
scores conveyed higher QOL.
Results
The response rate was 49.8%. Cronbach's α was 0.96. Immediate contralateral prophylactic
mastectomy (CPM) carried the highest interference (mean, 3.3148) with sexuality compared
with no CPM (mean, 2.85) or delayed CPM (P = .03). Breast conservation had the least interference with appearance (P < .01) and work and finances (P = .02).
Conclusions
Therapeutic mastectomy and CPM with or without reconstruction may adversely affect
QOL. These findings suggest that the choice and timing of interventions may significantly
affect patient satisfaction.
Keywords
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References
- Breast cancer facts and figures 2011-12.American Cancer Society, Atlanta, GA2012
Ries LAG, et al. SEER cancer statistics review 1975-2005. Available at: http://seer.cancer.gov/csr/1975_2005/.
- Impact of surgery and chemotherapy on the quality of life of younger women with breast carcinoma.Cancer. 2001; 92: 1288-1298
- Quality of life among younger women with breast cancer.J Clin Oncol. 2005; 23: 3322-3330
- Reliability and validity of the functional assessment of cancer therapy breast quality-of-life instrument.J Clin Oncol. 1997; 15: 974-986
- Quality of life in stage II breast cancer: an instrument for clinical trials.J Clin Oncol. 1988; 6: 1798-1810
- The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study.J Clin Oncol. 1996; 14: 2756-2768
- Body image and sexual problems in young women with breast cancer.Psycho-Oncology. 2006; 15: 579-594
- Premature ovarian failure and its consequences: vasomotor symptoms, sexuality, and fertility.J Clin Oncol. 2008; 26: 753-758
- Effect of esthetic outcome after breast-conserving surgery on psychosocial functioning and quality of life.J Clin Oncol. 2008; 26: 3331-3337
- Quality of life after breast carcinoma surgery.Cancer. 2001; 91: 1238-1246
- Sexual problems in younger women after breast cancer surgery.J Clin Oncol. 2006; 24: 2815-2821
- Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: a systematic review.J Natl Cancer Inst. 2012; 104: 386-405
- Quinn G. Vadaparampil S. Reproductive health and cancer. Springer, New York2012
- Having children after cancer.Cancer. 1999; 86: 697-709
- Discussion of fertility preservation with newly diagnosed patients: oncologists' views.J Cancer Surviv. 2007; 1: 146-155
- Trends of socioeconomic disparities in referral patterns for fertility preservation consultation.Hum Reprod. 2012; 27: 2076-2081
- Fertility preservation in women undergoing treatment for breast cancer in the U.K.: a questionnaire study.Oncologist. 2012; 17: 910-916
- The costs of treating breast cancer in the US: a synthesis of published evidence.Pharmacoeconomics. 2009; 27: 199-209
- Assessing the economic burden of breast cancer in a US managed care population.Breast Cancer Res Treat. 2008; 109: 367-377
- Patient time costs associated with cancer care.J Natl Cancer Inst. 2007; 99: 14-23
- Psychological reactions, quality of life, and body image after bilateral prophylactic mastectomy in women at high risk for breast cancer: a prospective 1-year follow-up study.J Clin Oncol. 2008; 26: 3943-3949
- Satisfaction after contralateral prophylactic mastectomy: the significance of mastectomy type, reconstructive complications, and body appearance.J Clin Oncol. 2005; 23: 7849-7856
- Contralateral prophylactic mastectomy in breast cancer patients with a family history: a prospective 2-years follow-up study of health related quality of life, sexuality and body image.Eur J Cancer. 2012; 48: 3150-3156
Article info
Publication history
Published online: September 09, 2013
Received in revised form:
August 6,
2013
Received:
May 21,
2013
Footnotes
This study was supported by the Pain and Palliative Care Department at Moffitt Cancer Center (Tampa, FL).
The authors declare no conflicts of interest.
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
