Abstract
Background
Given the role of gastrointestinal reconstruction, we investigated whether Roux-en-Y
gastrointestinal reconstruction (RYGR) and Billroth I reconstruction (B1R) can improve
glucose in nonobese type 2 diabetes mellitus patients.
Methods
Seventy-six nonobese type 2 diabetes mellitus patients underwent open subtotal gastrectomy
with RYGR and B1R between January 2005 and January 2010 in our hospital. Besides demographic
data, preoperative weight, glucose, hemoglobin A1c, ghrelin, and glucagon-like peptide
1 were determined.
Results
As defined previously, 2 of 35 patients with RYGR were cured, 5 patients were controlled,
and 10 patients were improved; similarly, 2 of 41 patients with B1R were controlled,
and 3 patients improved 12 months after surgery. The fasting glucose and hemoglobin
A1c decreased more significantly in RYGR patients (P < .05). Moreover, a higher fasting plasma GLP-1 level in RYGR patients and lower
ghrelin in B1R patients were noted after surgery (P < .05).
Conclusions
RYGR shows a more effective amelioration in nonobese type 2 diabetes mellitus patients.
Keywords
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Article info
Publication history
Published online: October 18, 2013
Received in revised form:
June 15,
2013
Received:
June 12,
2012
Footnotes
Supported by the National Natural Science Foundation of China (no. 81070642/H0713), Doctor Project of Ministry of Education (no. 20100131110049), and Outstanding Young Scientists Research Award Fund of Shandong Province (no. 2008BS03022).
The authors declare no conflict of interest.
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