Abstract
Background
Despite curative surgery for colorectal cancer, some patients experience tumor recurrence.
Whether early recurrence is associated with a shorter postrecurrence survival period
compared with late recurrence remains unknown.
Methods
A total of 395 patients with tumor recurrence after curative surgery for colorectal
cancer were enrolled and divided into early (<3 years) and late (≥3 years) recurrence
groups. Clinicopathologic characteristics, recurrence patterns, and postrecurrence
survival were compared.
Results
For stage I and II colorectal cancer, patients with T4 lesions tended to experience
early recurrence. For stage III colorectal cancer, early recurrence was more common
in patients with N2 disease. Patients with older age, mucinous-type tumors, poorly
differentiated histology, the presence of lymphovascular invasion, or multiple site
recurrence tended to die <2 years after recurrence. Median postrecurrence survival
was similar for the 2 groups. Patients undergoing resection of liver or lung metastases
demonstrated longer postrecurrence survival compared with those who did not undergo
resection.
Conclusions
Compared with late recurrence, early recurrence does not indicate a worse outcome
in colorectal cancer.
Keywords
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Article info
Publication history
Published online: November 12, 2013
Received in revised form:
July 23,
2013
Received:
June 18,
2013
Footnotes
This study was supported by research grants from the National Science Council (101-2314-B-075-023) and the Department of Medical Research & Education, Taipei Veterans General Hospital (V101B-006 and V102B-012).
The authors declare no conflicts of interest.
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
