Abstract
Background
We examined whether perioperative intensive insulin therapy (IIT) using an artificial
pancreas (AP) with a closed-loop glycemic control system can be used to prevent hypoglycemia
in surgical patients.
Methods
Between 2006 and 2012, perioperative glycemic control using an AP was performed in
427 patients undergoing general surgery. A total of 305 patients undergoing IIT using
an AP in the target blood glucose range of 80 to 110 mg/dL were enrolled in the study.
Data were collected prospectively and were reviewed or analyzed retrospectively.
Results
No patients had hypoglycemia. Perioperative mean blood glucose level and achievement
rates in target blood glucose range of 80 to 110 mg/dL were 100.5 ± 11.9 mg/dL and
88.1% ± 16.0%, respectively. For the 3 primary operative methods, including hepatic,
pancreatic, and esophageal resections, there were no significant differences in glycemic
control stability between the types of surgery.
Conclusion
Perioperative IIT using an AP with a closed-loop glycemic control system can be used
to prevent hypoglycemia and maintain stable glycemic control with less variability
of blood glucose concentration.
Keywords
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Article info
Publication history
Published online: January 06, 2014
Received in revised form:
June 25,
2013
Received:
January 10,
2013
Footnotes
Supported by the Japan Ministry of Education, Culture, Sports, Science, and Technology, The Kochi University President's Discretionary Grant, and grant from Nikkiso Co., Ltd.
The authors declare no conflicts of interest.
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
