Abstract
Background
Breast spindle cell malignancies are rare. No standard treatment exists.
Methods
The Surveillance, Epidemiology, and End Results database was used to identify patients
with breast spindle cell malignancies, 1992 to 2011. Descriptive statistical analysis
and survival analysis were performed.
Results
A total of 286 patients were identified (98.6% female). Approximately, 15% had estrogen
receptor–positive tumors and 12.5% had progesterone receptor–positive tumors. Nearly
38% underwent partial mastectomy, whereas 55.5% underwent mastectomy. The frequency
of partial mastectomy has increased in more recent years. One-third received radiation.
Lymph node metastases were infrequent (9.3%) and distant metastases were uncommon
(6.1%). Ten-year survival rates for patients with early-stage (I and II) disease were
83.9% after partial mastectomy, 86.7% after partial mastectomy plus radiation, and
71.6% after complete mastectomy. Three-year survival rates for patients with late-stage
(III and IV) disease were low with 40.0% after complete mastectomy and 0% after complete
mastectomy plus radiation.
Conclusions
This nationally representative analysis demonstrates that early-stage spindle cell
carcinoma of the breast is adequately treated by partial mastectomy. Radiation may
be considered for small, potentially early survival benefit. For late stage disease,
complete mastectomy is appropriate; however, survival is poor, and radiation contributes
no significant additional benefit.
Keywords
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Article info
Publication history
Published online: January 06, 2016
Received in revised form:
November 12,
2015
Received:
June 2,
2015
Footnotes
The authors declare no conflicts of interest.
Identification
Copyright
© 2016 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
