Highlights
- •This study was undertaken to determine if survival after resection of pancreatic adenocarcinoma has improved.
- •The SEER database was queried for patients who underwent pancreatectomy for pancreatic adenocarcinoma from 1992–2010.
- •From 1992–2010, patients lived more years but without improved 5-year survival.
Abstract
Introduction
This study was undertaken to determine if survival after resection of pancreatic adenocarcinoma
has improved over the past two decades.
Methods
The SEER database was queried for patients who underwent pancreatectomy for pancreatic
adenocarcinoma from 1992 to 2010. AJCC Stage and survival were determined for patients.
Data were analyzed using Mantel-Cox test and linear regression.
Results
15,604 patients underwent pancreatectomy from 1992 to 2010. Survival improved from
1992 to 2010 (p < 0.0001); specifically, median survival increased 1992–2010 (p < 0.0001).
However, 5-year survival rates did not change 1992–2010. More patients (p = 0.007)
underwent resections of Stage I and relatively more patients (p = 0.004) underwent
resections of Stage II cancers 2004–2010 with commensurately smaller tumors (p = 0.01).
Conclusions
From 1992 to 2010, progressively more patients underwent pancreatectomy for pancreatic
adenocarcinoma with progressively smaller tumors and earlier stages. These patients
lived more years (e.g., improved survival curves and median survival) but without
improved 5-year survival, denoting better early and intermediate survival. Early detection,
better perioperative care, more efficacious noncurative chemotherapy undoubtedly play
a role, but better solutions for long-term survival must be sought.
Keywords
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Article info
Publication history
Published online: June 03, 2017
Accepted:
May 12,
2017
Received in revised form:
May 9,
2017
Received:
March 9,
2017
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
