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Application of 21-gene recurrence score results and ASTRO suitability criteria in breast cancer patients treated with intraoperative radiation therapy (IORT)

      Highlights

      • The recurrence rate for IORT patients (mean follow-up: 55 months) was 5.4%.
      • ASTRO suitability criteria were useful in IORT patient selection.
      • 21-gene recurrence score provided predictive chemotherapy benefit for IORT patients.

      Abstract

      Background

      American Society for Radiation Oncology (ASTRO) suitability criteria for accelerated partial breast irradiation (APBI) and the 21-gene recurrence score (RS) were evaluated for prognostic and predictive benefit in IORT patients.

      Methods

      Outcomes of 184 patients completing IRB approved IORT protocol were retrospectively reviewed. Data included demographics, histopathology, RS, adjuvant therapy, locoregional (LRR) and distant recurrences (DR), and breast cancer-specific survival.

      Results

      There were 10 (5.4%) breast cancer recurrences, including one breast cancer-specific death. All 184 patients were classified by ASTRO suitability criteria (suitable: 64% (5 LRR), cautionary: 30% (3 LRR), unsuitable: 6.0% (1 LRR, 1 DR leading to death). RS were available in 114 estrogen receptor positive patients (<11: 22% (1 LRR), 11–25: 63% (1 LRR), 26–30: 9%, >30: 6%). Mean follow-up was 55 months.

      Conclusions

      ASTRO suitability criteria for APBI and RS were useful in making prognostic and therapeutic recommendations for patients considering IORT.

      Keywords

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