- •Lifetime breast cancer risk was calculated in mutation-negative women with a significant family history of breast cancer.
- •Over half of women with an uninformative negative genetic test result were identified as high-risk.
- •The Tyrer-Cuzick model identified the greatest proportion of high-risk women.
- •Women should not conclude that a negative genetic test result represents a lack of risk.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
- Global cancer statistics.CA Cancer J Clin. 2012. 2015; 65: 87-108https://doi.org/10.3322/caac.21262
- Beyond BRCA: new hereditary breast cancer susceptibility genes.Cancer Treat Rev. 2015; 41: 1-8https://doi.org/10.1016/j.ctrv.2014.10.008
- How many more breast cancer predisposition genes are there?.Breast Canc Res. 1999; 1: 14-17https://doi.org/10.1186/bcr6
- Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives: findings from the EMBRACE study.Genet Med. 2018; 20: 1575-1582https://doi.org/10.1038/gim.2018.44
- Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation.Br J Canc. 2009; 100: 421-425https://doi.org/10.1038/sj.bjc.6604830
- American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography.CA Cancer J Clin. 2007; 57: 75-89https://doi.org/10.3322/canjclin.57.2.75
- The calculation of breast cancer risk for women with a first degree family history of ovarian cancer.Breast Cancer Res Treat. 1993; 28: 115-120
- Projecting individualized probabilities of developing breast cancer for white females who are being examined annually.J Natl Cancer Inst. 1989; 81: 1879-1886https://doi.org/10.1093/jnci/81.24.1879
- A breast cancer prediction model incorporating familial and personal risk factors.Stat Med. 2004; 23: 1111-1130https://doi.org/10.1002/sim.1668
- Which risk model to use? Clinical implications of the ACS MRI screening guidelines.Cancer Epidemiol Biomark Prev. 2013; 22: 146-149https://doi.org/10.1158/1055-9965.EPI-12-0570
- Evaluation of breast cancer risk assessment packages in the family history evaluation and screening programme.J Med Genet. 2003; 40: 807-814https://doi.org/10.1136/jmg.40.11.807
- Addressing Breast Cancer Risk for Women in Families with Indeterminate Negative BRCA1 and BRCA2 Genetic Test Results..(Dissertation) The University of Utah, 2014