DR. STEPHANIE VALENTE (Cleveland, Ohio): As we heard, the authors evaluated 88 patients
with a strong family history of breast cancer who underwent genetic testing and were
negative. They used the term “uninformed result” because physicians don’t know how
to properly counsel or subsequently screen a patient with a strong family history
and subsequent negative genetic results. The results of the study showed that there
is a patient population at significant risk for developing breast cancer and that
the uninformative result patient should be further explored to identify proper individualized
high risk screening plan. Following the patients in this study long term to determine
concordance between risk calculation and further development of breast cancer will
be important.
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Article info
Publication history
Published online: November 07, 2019
Footnotes
☆(Presentation given by Ms. Caroline Breit, MS-2).
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Copyright
© 2019 Published by Elsevier Inc.
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Access this article on ScienceDirectLinked Article
- Breast cancer risk assessment in patients who test negative for a hereditary cancer syndromeThe American Journal of SurgeryVol. 219Issue 3
- PreviewThe majority of women who undergo genetic testing due to a significant family history of breast cancer will receive a negative result. Using three widely used risk assessment models, we calculated lifetime breast cancer risks of women who had undergone genetic testing and received a negative result. We found that over half of the women included in the study were considered to be high-risk for the development of breast cancer.
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