- •Breast cancer outcomes were compared in conforming and nonconforming elderly patients.
- •Nonconforming women were older than conforming women (80.5 vs. 77.7 years, P = 0.001).
- •Local recurrence and metastatic disease rates were similar between study groups.
- •Breast cancer related mortality was also similar between study groups.
- •Treatment nonconformity was not associated with poorer outcomes in elderly patients.
Aging remains one of the greatest risk factors for development of new breast cancer with more than 30% of breast cancers occurring after the age of 75. Elderly women have been found to not conform with all aspects of treatment recommendations. Our study compared outcomes of elderly breast cancer patients whose treatment did or did not conform to NCCN guidelines.
A retrospective review was conducted of breast cancer patients over the age of 70. Comparisons were made between patients whose treatment did or did not conform to NCCN guidelines for recurrence, metastatic disease, and breast cancer related deaths.
Patients whose treatment did not conform to NCCN guidelines were older (80.5 vs. 77.7 years, P = 0.001). No significant difference was seen between groups for tumor size, breast cancer type, or nodal status; however, more nonconforming women were ER/PR positive (90.3% vs. 76.6%, P = 0.020). There was no significant difference in local recurrence, metastatic disease, or breast cancer related deaths.
Women whose treatment did not conform to NCCN guidelines were not associated with worse outcomes.
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- Surgery improves breast cancer-specific survival in octogenarians with early-stage breast cancer.Int J Surg. 2013; 11: 554-557https://doi.org/10.1016/j.ijsu.2013.05.032
- Breast cancer in elderly women: presentation, survival, and treatment options.Surg Clin N Am. 1996; 76: 289-308
- Breast cancer in octogenarians.Cancer. 2006; 106: 1664-1668https://doi.org/10.1002/cncr.21788
- Female breast cancer management and survival: the experience of major public hospitals in South Australia over 3 decades-trends by age and in the elderly.J Eval Clin Pract. 2017; 23: 1433-1443https://doi.org/10.1111/jep.12819
- Breast cancer in the elderly-Should it be treated differently?.Rep Pract Oncol Radiother. 2012; 18: 26-33https://doi.org/10.1016/j.rpor.2012.05.005
- Breast cancer in the elderly: retrospective study on diagnosis and treatment according to national guidelines.Breast J. 2009; 15: 26-33https://doi.org/10.1111/j.1524-4741.2008.00667.x
- Octogenarians: noncompliance with breast cancer treatment recommendations.Am Surg. 2014; 80: 1119-1123
- National Comprehensive Cancer Network guidelines for breast cancer. National Comprehensive Cancer Network.(Available at:)www.nccn.org/professionals/physician_gls/f_guidelines.aspDate accessed: May 31, 2019
- SEER cancer statistics factsheets: breast cancer. National Cancer Institute. Bethesda, MD.(Available at:)https://seer.cancer.gov/statfacts/html/breast.htmlDate accessed: May 31, 2019
- Early primary breast cancer in the elderly - pattern of presentation and treatment.Surg Oncol. 2011; 20: 7-12https://doi.org/10.1016/j.suronc.2009.07.004
- Locoregional recurrence and survival rates after breast-conserving surgery and hormonal therapy in 70-year-old or older patients with Stage I or IIA breast carcinoma.Breast Care (Basel). 2013; 8: 134-137https://doi.org/10.1159/000350776
Published online: December 05, 2019
Accepted: December 3, 2019
Received in revised form: November 27, 2019
Received: June 18, 2019
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