Highlights
- •Breast cancer outcomes were compared in conforming and nonconforming elderly patients.
- •Nonconforming women were older than conforming women (80.5 vs. 77.7 years, P = 0.001).
- •Local recurrence and metastatic disease rates were similar between study groups.
- •Breast cancer related mortality was also similar between study groups.
- •Treatment nonconformity was not associated with poorer outcomes in elderly patients.
Abstract
Background
Aging remains one of the greatest risk factors for development of new breast cancer
with more than 30% of breast cancers occurring after the age of 75. Elderly women
have been found to not conform with all aspects of treatment recommendations. Our
study compared outcomes of elderly breast cancer patients whose treatment did or did
not conform to NCCN guidelines.
Methods
A retrospective review was conducted of breast cancer patients over the age of 70.
Comparisons were made between patients whose treatment did or did not conform to NCCN
guidelines for recurrence, metastatic disease, and breast cancer related deaths.
Results
Patients whose treatment did not conform to NCCN guidelines were older (80.5 vs. 77.7
years, P = 0.001). No significant difference was seen between groups for tumor size, breast
cancer type, or nodal status; however, more nonconforming women were ER/PR positive
(90.3% vs. 76.6%, P = 0.020). There was no significant difference in local recurrence, metastatic disease,
or breast cancer related deaths.
Conclusions
Women whose treatment did not conform to NCCN guidelines were not associated with
worse outcomes.
Keywords
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Article info
Publication history
Published online: December 05, 2019
Accepted:
December 3,
2019
Received in revised form:
November 27,
2019
Received:
June 18,
2019
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.
