Highlights
- •A pool of 18,103 patients was found in Pubmed and Web of Science for meta-analysis.
- •Oncoplastic surgery cancer recurrence rates were not significantly different to traditional methods.
- •Re-operation rates were also not significantly different to established techniques.
- •Oncoplastic breast conserving surgery is a safe alternative to traditional procedures.
Abstract
Background
Oncoplastic Breast Conserving Surgery (OBCS) allows adequate resection margins of
tumours unsuitable for standard breast conserving surgery (SBCS) whilst allowing for
better cosmesis and reduced morbidity when compared to mastectomy. However, there
is limited evidence on its oncological safety.
Methods
This study aims to compare oncological safety of OBCS with SBCS and mastectomy by
examining the relative risk of cancer recurrence and re-operation rates through meta-analysis.
Results
18 studies met the search criteria including 18,103 patients. The primary outcome
measure (recurrence) was not significantly different between OBCS and SBCS or mastectomy
(RR 0.861; 95% CI 0.640–1.160; p = 0.296). The secondary outcome measure (re-operation)
initially achieved significance in favour of OBCS (RR 0.64; 95% CI 0.46–0.89; p = 0.01).
However, after adjustment for publication bias this was attenuated to insignificance
between the two study groups (RR 0.86; 95% CI 0.56–1.31; p = 0.44).
Conclusions
For both cancer recurrence and re-operation rate, there was no significant difference
between OBCS and traditional techniques. OBCS is of comparable oncological safety
to more established surgical procedures and a useful option in suitable patients.
Keywords
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Article info
Publication history
Published online: January 02, 2020
Accepted:
December 13,
2019
Received in revised form:
November 10,
2019
Received:
September 14,
2019
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
