Research Article| Volume 220, ISSUE 2, P448-453, August 2020

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Association of metabolic syndrome with morbidity and mortality in emergency general surgery

Published:December 21, 2019DOI:


      • Among EGS patients MetS increases morbidity and hospital readmission risk.
      • MetS had the strongest negative effect on appendectomy and increased mortality.
      • Specific complications to be expected are infective, renal, and pulmonary in nature.



      Metabolic syndrome (MetS) is defined by numerous comorbidities. We sought to assess MetS’s effect on the 7 main emergency general surgery (EGS) procedures that constitute 80% of EGS procedures, mortalities, complications, and costs.


      Data were acquired from the ACS-NSQIP database from 2005 to 2017. Current procedural terminology (CPT) codes were utilized to identify cases. Patients with obesity, diabetes, and hypertension were defined as having MetS. MetS and non-MetS cohorts were propensity score matched, compared by outcomes, and assessed with multivariate logistic regression to attain odds ratios (OR).


      Of 752,023 cases, 41,788 (5.6%) MetS cases were identified. Significant outcomes included superficial infection (OR: 1.51), pulmonary complications (OR: 1.17), renal complications (OR: 1.82), cumulative morbidity (OR: 1.22), and hospital readmission (OR: 1.41).


      For patients undergoing these procedures, MetS increased risk for comorbidities and hospital readmission. MetS had a significant impact on mortality only for appendectomy.


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