- •Restrictive intra-operative fluids did not increase post-operative AKI rates.
- •Restrictive fluids associated with reduced Clavien-Dindo I-II complications.
- •Longer length of surgery associated with post-operative acute kidney injury.
The amount of IV fluids sufficient to prevent post-operative acute kidney injury (AKI) during pancreaticoduodenectomy (PD) is unknown. We assessed the restrictive IOIVF use in PD on the rate of post-operative AKI, delayed gastric emptying and ileus, and pancreatic fistulas (POPF).
Patients who underwent PD between 2012 and 2017 were reviewed. Univariate and multivariate analyses looked for association between pre- and intra-operative factors on AKI, ileus and POPF.
Of 395 included patients, 97, 172, and 126 patients received less than 1000 mL (ultra-restrictive), 1000 mL to less than 2000 mL (restrictive), and 2000 mL and greater (nonrestrictive) normalized total IOIVF respectively. Of these 23 (24.2%), 34(20.4%), and 21(17.4%) developed AKI respectively, most of them mild. There was no difference in odds of developing AKI, ileus, or pancreatic fistula among fluid groups. While there was no difference in Clavien-Dindo III-IV complications, the incidence of Clavien-Dindo type I-II complications was lower in the restricted fluid groups.
Restricted fluids did not lead to higher AKI rates but were associated with fewer low-grade complications.
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Published online: March 23, 2020
Accepted: March 19, 2020
Received in revised form: March 8, 2020
Received: November 25, 2019
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