The issue of optimal fluid management for patients undergoing pancreatoduodenectomy
(PD) has drawn a great deal of interest and investigation in recent years.
1
,
- Fisher M.
- Matsuo K.
- Gonen M.
- et al.
Relationship between intraoperative fluid administration and perioperative outcomes
after pancreatoduodenectomy: results of a prospective randomized trial of acute normovolemic
hemodilution compared with standard intraoperative management.
Ann Surg. 2010; 252: 952-958
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In fact, four randomized controlled trials with a focus on PD have been performed.
1
,- Fisher M.
- Matsuo K.
- Gonen M.
- et al.
Relationship between intraoperative fluid administration and perioperative outcomes
after pancreatoduodenectomy: results of a prospective randomized trial of acute normovolemic
hemodilution compared with standard intraoperative management.
Ann Surg. 2010; 252: 952-958
3
,
4
,
5
Pancreatoduodenectomy draws attention because the operation is long and, in the past,
has required significant fluid administration. As a result, major fluid shifts between
the interstitial and intravascular spaces occur in the operating room and postoperatively.
In addition, while operative mortality has improved dramatically over the past half
century, PD continues to be associated with a frustratingly high postoperative morbidity
rate.To read this article in full you will need to make a payment
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References
- Relationship between intraoperative fluid administration and perioperative outcomes after pancreatoduodenectomy: results of a prospective randomized trial of acute normovolemic hemodilution compared with standard intraoperative management.Ann Surg. 2010; 252: 952-958
- Effect of intra-operative fluid volume on peri-operative outcomes after pancreaticoduodenectomy for pancreatic adenocarcinoma.J Surg Oncol. 2012; 105: 81-84
- A prospective randomized controlled trial of the use of a restrictive fluid regimen with 3% hypertonic saline versus lactatad Ringers in patients undergoing pancreaticoduodenectomy.Ann Surg. 2014; 260: 445-455
- Intraoperative fluid restriction in pancreatic surgery: a double blinded randomized controlled trial.PloS One. 2015; 10: 1-15
- Restrictive intraoperative fluid optimization algorithm improves outcomes in patients undergoing pancreaticoduodenectomy: a prospective multicentre randomized controlled trial.PloS One. 2017; 12
- Clinical implications of intraoperative fluid therapy in pancreatic surgery.J Gastrointest Surg. 2018; 22: 2072-2079
- Fluid restriction during pancreaticoduodenectomy: is it effective in reducing postoperative complications?.Adv Surg. 2015; 49: 205-220
- Ultrarestrictive intraoperative intravenous fluids during pancreatoduodenectomy is not associated with an increase in post-operative acute kidney injury.Am J Surg. 2020; 220: 264-269
- Two open whipples a day: excessive or efficient.Am J Surg. 2020; 219: 394-395
Article info
Publication history
Published online: May 03, 2020
Accepted:
April 19,
2020
Received:
April 19,
2020
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
