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Cancer risk estimation using American College of Radiology Thyroid Imaging Reporting and Data System for cytologically indeterminate thyroid nodules

      Highlights

      • Combining TI-RADS score with Bethesda diagnostic grouping allows for more accurate preoperative thyroid nodule ROM estimation.
      • TI-RADS score of 5 increases the ROM estimation for thyroid nodules with any Bethesda diagnosis.
      • For Bethesda diagnostic groupings less than VI, the TI-RADS score was more predictive of ROM.

      Abstract

      Background

      We sought to determine if using the ACR TI-RADS ultrasound score combined with the Bethesda diagnosis can help augment thyroid cancer risk estimation.

      Methods

      TI-RADS scores and Bethesda diagnoses were collected for patients treated in our center who had undergone thyroidectomy. Data from 186 patients with both TI-RADS scores and Bethesda diagnosis, and Bethesda diagnosis alone, were analyzed by multivariable regression analysis and observed for whether the pathology was benign or malignant.

      Results

      The regression analysis model showed that as the TI-RADS score increases, the odds of malignancy increases as well. The predictive value of the odds of malignancy in a thyroid nodule using both Bethesda diagnosis and TI-RADS score together was more powerful than the odds given using the Bethesda diagnosis alone.

      Conclusions

      Our model shows that the ACR TI-RADS score may assist with preoperative decision-making for patients with cytologically indeterminate thyroid nodules when combined with Bethesda diagnosis.

      Keywords

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