Highlights
- •68Ga-DOTATATE-PET has a role in imaging MTC patients with suspected recurrence.
- •68Ga-DOTATATE-PET may be complementary to 18F-FDG-PET when imaging MTC patients for recurrence.
- •The cost and technicalities of 68Ga-DOTATATE-PET should be considered.
Abstract
Background
Many patients with Medullary Thyroid Cancer (MTC) will have persistent or recurrent
disease after surgery requiring lifelong surveillance with imaging and tumor markers.
The objective of this study is to evaluate the efficacy of 68Ga-DOTATATE-PET (or 68Ga labelled equivalent radiopharmaceutical) versus 18F-FDG-PET for detecting persistent and/or metastatic recurrent MTC.
Methods
Relevant studies were identified by conducting searches in Embase and PubMed and five
studies were included in the final review.
Results
Five studies investigated per-patient sensitivity of 18F-FDG-PET and 68Ga-DOTATATE-PET in MTC patients. Four studies investigated the correlation between
calcitonin and number of lesions detected by 18F-FDG-PET and 68Ga-DOTATATE-PET, and three investigated the correlation between CEA and number of
lesions detected by 18F-FDG-PET and 68Ga-DOTATATE-PET. There was no significant difference in number of lesions detected
by 18F-FDG -PET compared with 68Ga-DOTATATE-PET.
Conclusions
When compared directly to 18F-FDG-PET, there is a general trend towards favoring 68Ga-DOTATATE-PET in per-patient sensitivities, and incidence of lesion detection.
Keywords
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Article Info
Publication History
Published online: March 29, 2022
Accepted:
March 25,
2022
Received in revised form:
February 15,
2022
Received:
November 12,
2021
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
