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Discovering domains important to health-related quality of life in differentiated thyroid cancer

      The incidence of differentiated thyroid cancer (DTC) has increased sharply in high-income countries over the last few decades; however, prognosis remains excellent, with 5-year survival rates above 95% even with regional disease spread. Health-related quality of life (HRQOL) is therefore a critical outcome measure in DTC, as complications from treatment can result in lifelong morbidity. Understanding factors that HRQOL after surgery can guide patient-centered care, from decisions on surgical extent to provision of resources to optimize patients’ postoperative psychosocial well-being, and enable further refinement of current HRQOL assessment tools. Existing tools to measure HRQOL include general or disease-specific domains of well-being. The validated THYCA-QoL assessment focuses on common symptoms caused by thyroid cancer and its treatment, including voice changes, hypocalcemia-related complaints, mood disturbances, and fatigue.
      • Husson O.
      • Haak H.R.
      • Mols F.
      • et al.
      Development of a disease-specific health-related quality of life questionnaire (THYCA-QoL) for thyroid cancer survivors.
      Yet, additional factors not captured in the assessment may modulate the subjective experience of these symptoms and independently affect HRQOL.
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      References

        • Husson O.
        • Haak H.R.
        • Mols F.
        • et al.
        Development of a disease-specific health-related quality of life questionnaire (THYCA-QoL) for thyroid cancer survivors.
        Acta Oncol. Feb. 2013; 52: 447-454https://doi.org/10.3109/0284186X.2012.718445
        • Aaronson N.K.
        • Ahmedzai S.
        • Bergman B.
        • et al.
        The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology.
        J Natl Cancer Inst. Mar 3. 1993; 85: 365-376
        • Bhandari N.R.
        • Kathe N.
        • Hayes C.
        • Payakachat N.
        Reliability and validity of SF-12v2 among adults with self-reported cancer.
        Res Soc Adm Pharm. 2018; 14: 1080-1084
        • Morozova O.
        • Levina O.
        • Uusküla A.
        • Heimer R.
        Comparison of subset selection methods in linear regression in the context of health-related quality of life and substance abuse in Russia.
        BMC Med Res Methodol. 2015; 15: 1-17
        • Mu W.
        • Muriello M.
        • Clemens J.L.
        • et al.
        Factors affecting quality of life in children and adolescents with hypermobile Ehlers‐Danlos syndrome/hypermobility spectrum disorders.
        Am J Med Genet. 2019; 179: 561-569
        • Pedregosa F.
        • Varoquaux G.
        • Gramfort A.
        • et al.
        Scikit-learn: machine learning in Python.
        J Mach Learn Res. 2011; 12: 2825-2830
        • Abdel Majeed Y.
        • Awadalla S.S.
        • Patton J.L.
        Regression techniques employing feature selection to predict clinical outcomes in stroke.
        PLoS One. 2018; 13e0205639https://doi.org/10.1371/journal.pone.0205639
        • Mongelli M.N.
        • Giri S.
        • Peipert B.J.
        • Helenowski I.B.
        • Yount S.E.
        • Sturgeon C.
        Financial burden and quality of life among thyroid cancer survivors.
        Surgery. 2020; 167: 631-637