Discovering domains important to health-related quality of life in differentiated thyroid cancer

      The incidence of differentiated thyroid cancer (DTC) has increased sharply in high-income countries over the last few decades; however, prognosis remains excellent, with 5-year survival rates above 95% even with regional disease spread. Health-related quality of life (HRQOL) is therefore a critical outcome measure in DTC, as complications from treatment can result in lifelong morbidity. Understanding factors that HRQOL after surgery can guide patient-centered care, from decisions on surgical extent to provision of resources to optimize patients’ postoperative psychosocial well-being, and enable further refinement of current HRQOL assessment tools. Existing tools to measure HRQOL include general or disease-specific domains of well-being. The validated THYCA-QoL assessment focuses on common symptoms caused by thyroid cancer and its treatment, including voice changes, hypocalcemia-related complaints, mood disturbances, and fatigue.
      • Husson O.
      • Haak H.R.
      • Mols F.
      • et al.
      Development of a disease-specific health-related quality of life questionnaire (THYCA-QoL) for thyroid cancer survivors.
      Yet, additional factors not captured in the assessment may modulate the subjective experience of these symptoms and independently affect HRQOL.
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