Highlights
- •Post-operative pancreatic fistula is higher in pancreatic neuroendocrine tumors.
- •Male sex, pancreaticoduodenectomy, small duct, and soft gland have higher leak rate.
- •Tumor stage, nodes, metastasis, race, and age were not associated with leak rate.
- •Functioning and non-functioning tumors had similar post-operative leak rates.
- •Post-operative pancreatic fistula rates did not change between 2014 and 2018.
Abstract
Background
Post-operative pancreatic fistula (POPF) is a serious complication following pancreas
surgery. We aimed to establish factors associated with POPF specifically in patients
with pancreatic neuroendocrine tumors (PNET).
Methods
The 2014–2018 American College of Surgeons National Surgical Quality Improvement Program
database was querried for patients undergoing resection for PNET. The impact of patient,
tumor, and operative factors on POPF formation was evaluated.
Results
3532 patient underwent resections for PNET. The POPF rate was significantly higher
in patients with PNET (24.8%) versus non-PNET (16.4%) (p < 0.0001). Male sex (OR 1.45,
95% CI 1.11–1.89), enucleation (OR 3.14, 95% CI 1.10–8.98), pancreaticoduodenectomy
(OR 1.51, 95% CI 1.13–2.03), small duct size <3 mm (OR 3.24, 95% CI 1.62–6.48), and
soft gland texture (OR 1.81, 95% CI 1.18–2.77) were independently associated with
POPF in PNET patients on multivariable analysis.
Conclusions
POPF is more common in patients undergoing resection for PNET and is dictated primarily
by surgical approach and gland characteristics.
Keywords
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Article info
Publication history
Published online: August 09, 2022
Accepted:
July 14,
2022
Received in revised form:
June 4,
2022
Received:
February 8,
2022
Identification
Copyright
Published by Elsevier Inc.
