Highlights
- •Hyperparathyroid crisis is rare, occurring in 2.4% of hyperparathyroidism patients.
- •Manifested by more severe primary hyperparathyroidism with larger glands.
- •Parathyroid glands more often ectopic and malignant.
- •Higher rate of recurrence and mortality than hyperparathyroidism without crisis.
Abstract
Background
Hyperparathyroid crisis (HPTC) is a potentially lethal condition characterized by
severe symptomatic hypercalcemia with calcium levels ≥14 mg/dl. We sought to determine
the rate of HPTC and how it differs from hyperparathyroidism (HPT) without crisis
(HPTWC).
Methods
A retrospective review of patients with surgically treated HPT from 1990 to 2022 was
completed.
Results
HPTC occurred in 18 (2.4%) of 783 with primary HPT. Patients with HPTC had higher
preoperative calcium and parathyroid hormone levels, lower postoperative calcium levels,
larger gland weights and higher rates of ectopic glands, carcinoma, recurrence and
mortality compared to patients with HPTWC (all p < 0.05).
Conclusions
HPTC is a rare condition manifested by severe HPT that is associated with a higher
rate of recurrence and mortality compared to HPTWC. HPTC is associated with larger
parathyroid glands that are more often ectopic and malignant.
Graphical abstract
Graphical Abstract
Keywords
Abbreviations:
HPTC (Hyperparathyroid crisis), HPT (Hyperparathyoidism), HPTWC (Hyperparathyroidism without crisis)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: October 18, 2022
Accepted:
October 13,
2022
Received in revised form:
September 24,
2022
Received:
June 13,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
