Highlights
- •MCN during pregnancy may be more aggressive.
- •They are more symptomatic during pregnancy when compared to general population.
- •Despite evidence of aggressive growth, no significant difference in tumour biology is reported when associated with pregnancy.
- •No definitive correlation between receptor expression profile and rate of tumour growth of MCN during pregnancy is reported.
- •Surgical decision making is complex and emphasis should be on the safety of both mother and child.
Abstract
Introduction
Mucinous cystic neoplasms (MCN) are mucin-producing epithelial cell tumors of pancreas.
They consist of an ovarian-type stroma expressing estrogen and progesterone receptors.
Pregnancy-associated MCNs are presumed to be larger in size and more aggressive without
any concrete evidence.
Objective
and Data Sources: Systematic review of published literature using PubMed and Google Scholar databases.
Original articles including case reports and series published between 1970&2021 were
included wherein MCN was diagnosed during pregnancy/within one-year post-partum. Thirty-three
publications having 36 cases, adding one of our own patient were analyzed in this
review.
Result
Median age at presentation was 32 years. Only three (9%) patients were asymptomatic.
Mean size of MCN was 135 mm. Ten patients (27%) reported an increase in size during
pregnancy. Most tumors involved body and tail of pancreas (60%). Distal pancreatectomy
with splenectomy was the most common resection performed (57%). No foetal mortality
was reported to date.
Conclusion
Pregnancy may cause a rapid increase in size of MCN. Decision-making is more complex
and needs a fine balance between optimal oncological and obstetric outcomes.
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Article info
Publication history
Published online: November 16, 2022
Accepted:
November 2,
2022
Received:
October 29,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
