Simultaneous versus staged resection for synchronous colorectal liver metastases: The win ratio approach

Published:November 19, 2022DOI:


      • The optimal strategy of synchronous colorectal liver metastases (sCRLM) is unsolved.
      • The win ratio (WR) is used to analyze the hierarchical composite endpoints.
      • The WR is increasingly utilized for more “patients-centric” viewpoints.
      • Staged resection was superior to simultaneous resection for sCRLM based on the WR.
      • The WR was higher when major hepatectomy was needed.



      In order to investigate the optimal approach for synchronous colorectal liver metastases (sCRLM), we sought to use the “win ratio” (WR), a novel statistical approach, to assess the relative benefit of simultaneous versus staged surgical treatment.


      Patients who underwent hepatectomy for sCRLM between 2008 and 2020 were identified from a multi-institutional database. The WR approach was utilized to compare composite outcomes of patients undergoing simultaneous versus staged resection.


      Among 1116 patients, 642 (57.5%) presented with sCRLM; 290 (45.2%) underwent simultaneous resection, while 352 (54.8%) underwent staged resection. In assessing the composite outcome, staged resection yielded a WR of 1.59 (95%CI 1.47–1.71) over the simultaneous approach for sCRLM. The highest WR occurred among patients requiring major hepatectomy (WR = 1.93, 95%CI 1.77–2.10) compared with patients who required minor liver resection (WR = 1.55, 95%CI 1.44–1.70).


      Staged resection was superior to simultaneous resection for sCRLM based on a WR assessment.


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