- •Retrospective study on patients who underwent total or completion thyroidectomy.
- •Machine learning utilized to find predictors of levothyroxine dosing.
- •Algorithms found race and ethnicity significantly associated with dosing.
- •Alcohol use and osteoarthritis were also associated with dosing.
- •Confirmed previously known factors: weight, BMI, age, and sex.
Abbreviations:BMI (Body Mass Index), BSA (Body Surface Area), LBM (Lean Body Mass), ML (Machine Learning), TSH (Thyroid Stimulating Hormone), XGBoost (Extreme Gradient Boost), FNN (Feedforward Neural Network), HTN (Hypertension), GERD (Gastroesophageal Reflux Disease), COPD (Chronic Obstructive Pulmonary Disease)
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- Optimization of thyroxine replacement therapy after total or near-total thyroidectomy for benign thyroid disease.Br J Surg. 2005; 93: 57-60https://doi.org/10.1002/bjs.5157
- Optimizing levothyroxine dose adjustment after thyroidectomy with a decision tree.J Surg Res. 2019; 244: 102-106https://doi.org/10.1016/j.jss.2019.06.025
- Predicting thyroxine requirements following total thyroidectomy.Clin Endocrinol. 2011; 74: 384-387https://doi.org/10.1111/j.1365-2265.2010.03940.x
- Prospective intervention of a novel levothyroxine dosing protocol based on body mass index after thyroidectomy.J Am Coll Surg. 2016; 222: 6
- The optimal levothyroxine dosing scheme After thyroidectomy: a comprehensive comparison and evaluation.Surgery. 2019; 165: 92-98https://doi.org/10.1016/j.surg.2018.04.097
- Thyroid hormone suppression therapy.Endocrinol Metab Clin N Am. 2019; 48: 227-237https://doi.org/10.1016/j.ecl.2018.10.008
- Effects on bone mass of long term treatment with thyroid hormones: a meta-analysis.J Clin Endocrinol Metab. 1996; 81: 4278-4289https://doi.org/10.1210/jcem.81.12.8954028
- Effects of thyroid hormone on the cardiovascular system.https://core.ac.uk/reader/54946347?utm_source=linkoutDate accessed: April 12, 2021
Sawin CT, Geller A, Wolf PA, et al. Low Serum Thyrotropin Concentrations as a Risk Factor for Atrial Fibrillation in Older Persons. https://doi.org/10.1056/NEJM199411103311901. doi:10.1056/NEJM199411103311901.
- Risk for fracture in women with low serum levels of thyroid-stimulating hormone.Ann Intern Med. 2001; 134: 561-568https://doi.org/10.7326/0003-4819-134-7-200104030-00009
- The economic impact of levothyroxine dose adjustments: the CONTROL HE study.Clin Drug Invest. 2017; 37: 71-83https://doi.org/10.1007/s40261-016-0462-3
- Evaluation of thyroid hormone replacement dosing in overweight and obese patients after a thyroidectomy.Thyroid. 2019; 29: 1558-1562https://doi.org/10.1089/thy.2019.0251
- Using body mass index to predict optimal thyroid dosing after thyroidectomy.J Am Coll Surg. 2013; 216: 7
- A new strategy to estimate levothyroxine requirement after total thyroidectomy for benign thyroid disease.Thyroid. 2014; 24: 1759-1764https://doi.org/10.1089/thy.2014.0111
- Lean body mass is a predictor of the daily requirement for thyroid hormone in older men and women.J Am Geriatr Soc. 1984; 32: 204-207https://doi.org/10.1111/j.1532-5415.1984.tb02003.x
- Thyroid hormone signaling in energy homeostasis and energy metabolism.Ann N Y Acad Sci. 2014; 1311: 77-87https://doi.org/10.1111/nyas.12374
- Racial disparities in metabolism, central obesity, and sex hormone-binding globulin in postmenopausal Women 1.J Clin Endocrinol Metab. 2001; 86: 97-103https://doi.org/10.1210/jcem.86.1.7147
- Differences in resting metabolic rate between white and African-American young adults.Obes Res. 2002; 10: 726-732https://doi.org/10.1038/oby.2002.99
- Bayesian network to predict breast cancer risk of mammographic microcalcifications and reduce number of benign biopsy results: initial experience.Radiology. 2006; 240: 666-673https://doi.org/10.1148/radiol.2403051096
- Systematic review of machine learning models for personalised dosing of heparin.Br J Clin Pharmacol. 2021; 87: 4124-4139https://doi.org/10.1111/bcp.14852
- Guidelines for the treatment of hypothyroidism: prepared by the American thyroid association task force on thyroid hormone replacement.Thyroid. 2014; 24: 1670-1751https://doi.org/10.1089/thy.2014.0028
- Cigarette smoking is associated with higher thyroid hormone and lower TSH levels: the PREVEND study.Endocrine. 2020; 67: 613-622https://doi.org/10.1007/s12020-019-02125-2
- Hypertension and race/ethnicity.Curr Opin Cardiol. 2020; 35: 342-350https://doi.org/10.1097/HCO.0000000000000742
- Obesity and diabetes in blacks.Diabetes Care. 1990; 13: 1144-1149https://doi.org/10.2337/diacare.13.11.1144
- Pilot study to evaluate the safety, feasibility, and financial implications of a postoperative telemedicine program.Ann Surg. 2018; 268: 700-707https://doi.org/10.1097/SLA.0000000000002931
- Current applications and future impact of machine learning in radiology.Radiology. 2018; 288: 318-328https://doi.org/10.1148/radiol.2018171820
- Artificial intelligence for mammography and digital breast tomosynthesis: current concepts and future perspectives.Radiology. 2019; 293: 246-259https://doi.org/10.1148/radiol.2019182627
- Levothyroxine replacement dosage determination after thyroidectomy.Am J Surg. 2013; 205 (; discussion 363-364): 360-363https://doi.org/10.1016/j.amjsurg.2012.10.015
- Assessment of physical activity and energy expenditure: an overview of objective measures.Front Nutr. 2014; 1: 5https://doi.org/10.3389/fnut.2014.00005
- Comparison of dosing schemes for thyroid hormone replacement therapy after thyroidectomy.J Surg Res. 2021; 264: 316-320https://doi.org/10.1016/j.jss.2021.03.016
- Is the replication crisis a base-rate fallacy?.Theor Med Bioeth. 2021; 42: 233-243https://doi.org/10.1007/s11017-022-09561-8
- The crisis of reproducibility, the denominator problem and the scientific role of multi-scale modeling.Bull Math Biol. 2018; 80: 3071-3080https://doi.org/10.1007/s11538-018-0497-0