Highlights
- •Preoperative mIMAC might be surrogate marker for aging and nutritional status in esophageal cancer patients.
Abstract
Background
Sarcopenia consists of two dysregulation patterns of body composition, myopenia and
myosteatosis. The aim of this study is to compare the preoperative status of various
body composition indexes including our newly developed modified intramuscular adipose
tissue content (mIMAC) to investigate these clinical values in esophageal cancer patients.
Method
We assessed preoperative psoas muscle mass index (PMI), IMAC, and mIMAC in 150 esophageal
cancer patients.
Results
Preoperative high IMAC and low mIMAC status were significantly associated with older
age. Preoperative decreased mIMAC was significantly associated with advanced T classification
and the presence of distant metastasis and low preoperative mIMAC was an independent
prognostic factor for poor overall survival and disease-free survival in esophageal
cancer patients. Combined assessment of preoperative mIMAC with PMI could help stratify
risk for oncological outcomes. Finally, preoperative PMI and mIMAC were positively
correlated with various nutritional factors in esophageal cancer patients.
Conclusion
Combined assessment between preoperative PMI and mIMAC could stratify risk for oncological
outcomes, and preoperative mIMAC might be surrogate marker for aging and nutritional
status in esophageal cancer patients.
Keywords
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Article info
Publication history
Published online: November 28, 2022
Accepted:
November 27,
2022
Received in revised form:
November 25,
2022
Received:
September 19,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
