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Combined assessment of muscle quality and quantity predicts oncological outcome in patients with esophageal cancer

  • Takahito Kitajima
    Affiliations
    Department of Genomic Medicine, Mie University Hospital, Japan

    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Yoshinaga Okugawa
    Correspondence
    Corresponding author. Department of Genomic Medicine, Mie University Hospital, 2-174, Edobashi, Tsu, Mie, 514-8507, Japan.
    Affiliations
    Department of Genomic Medicine, Mie University Hospital, Japan

    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Tadanobu Shimura
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Shinji Yamashita
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Yuhki Sato
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Arul Goel
    Affiliations
    La Canada High School, La Canada Flintridge, CA, 91011, USA
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  • Naru Mizuno
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Chengzeng Yin
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Rho Uratani
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Hiroki Imaoka
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Yuhki Morimoto
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Mikio Kawamura
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Ikuyo Mochiki
    Affiliations
    Department of Genomic Medicine, Mie University Hospital, Japan
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  • Yoshiki Okita
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Takeshi Yokoe
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Masaki Ohi
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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  • Yuji Toiyama
    Correspondence
    Corresponding author.
    Affiliations
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
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Published:November 28, 2022DOI:https://doi.org/10.1016/j.amjsurg.2022.11.032

      Highlights

      • Preoperative mIMAC might be surrogate marker for aging and nutritional status in esophageal cancer patients.

      Abstract

      Background

      Sarcopenia consists of two dysregulation patterns of body composition, myopenia and myosteatosis. The aim of this study is to compare the preoperative status of various body composition indexes including our newly developed modified intramuscular adipose tissue content (mIMAC) to investigate these clinical values in esophageal cancer patients.

      Method

      We assessed preoperative psoas muscle mass index (PMI), IMAC, and mIMAC in 150 esophageal cancer patients.

      Results

      Preoperative high IMAC and low mIMAC status were significantly associated with older age. Preoperative decreased mIMAC was significantly associated with advanced T classification and the presence of distant metastasis and low preoperative mIMAC was an independent prognostic factor for poor overall survival and disease-free survival in esophageal cancer patients. Combined assessment of preoperative mIMAC with PMI could help stratify risk for oncological outcomes. Finally, preoperative PMI and mIMAC were positively correlated with various nutritional factors in esophageal cancer patients.

      Conclusion

      Combined assessment between preoperative PMI and mIMAC could stratify risk for oncological outcomes, and preoperative mIMAC might be surrogate marker for aging and nutritional status in esophageal cancer patients.

      Keywords

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