Highlights
- •Opioid prescriptions are common in NP.
- •Despite decline over time, 1 in 4 patients remain on opioids at disease resolution.
- •These data identify an opportunity to adjust analgesic prescription practice in NP patients.
Abstract
Background
Rates of opioid usage during necrotizing pancreatitis (NP) disease course are unknown.
We hypothesized that a significant number of NP patients were prescribed opioid analgesics
chronically.
Methods
Single institution IRB-approved retrospective study of 230 NP patients treated between
2015 and 2019.
Results
Data were available for 198/230 (86%) patients. 166/198 (84%) were discharged from
their index hospitalization with a prescription for an opioid. At the first clinic
visit following hospitalization, 110/182 (60%) were using opioids. Six months after
disease onset, 72/163 (44%) continued to require opioids. At disease resolution, 38/144
(26%) patients remained on opioid medications. The rate of active opioid prescriptions
at six months after disease onset declined throughout the period studied from 68%
in 2015 to 39% in 2019.
Conclusions
Opioid prescriptions are common in NP. Despite decline over time, 1 in 4 patients
remain on opioids at disease resolution. These data identify an opportunity to adjust
analgesic prescription practice in NP patients.
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Article info
Publication history
Accepted:
November 29,
2022
Received in revised form:
November 20,
2022
Received:
July 8,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
