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Outcomes of liver resection for huge hepatocellular carcinoma exceeding 10 cm in size: A single center experience

Published:December 06, 2022DOI:https://doi.org/10.1016/j.amjsurg.2022.12.005

      Highlights

      • HCCs may be diagnosed at a more locally advanced status and with huge sizes (exceeding 10 cm in diameter).
      • Therapeutic modalities for patients with huge HCCs (exceeding 10 cm in diameter) are limited.
      • Liver resection for HCCs exceeding 10 cm in size is associated with acceptable perioperative morbidities and mortality.
      • Liver resection is associated with acceptable progression free survival but worser overall survival.
      • Proper case selection, adequate techniques and standardized care can provide favorable patients' survival.

      Abstract

      Background

      To evaluate our experience of resection for huge hepatocellular carcinoma (HCC) (exceeding 10 cm in diameter).

      Methods

      We reviewed the patients’ data who underwent liver resection for huge HCC between 2010 and 2019. We divided them into two groups according to liver resection extent (minor/major).

      Results

      40 patients were included. Minor Group included 19 patients (47.5%), and Major Group included 21 patients (52.5%). Longer operation time, hospital stay, and more severe complications were found in Major Group.
      The 1-, 3-, and 5-years OS rates were 76.6%, 39.5%, and 39.5%, respectively. The 1-, 3-, and 5-year DFS rates were 65.6%, 40%, and 0%, respectively. There were no significant differences between the two groups regarding OS (p = 0.598) and DFS (p = 0.564).

      Conclusion

      Liver resection for huge HCC is associated with average morbidities and mortality. Proper selection, adequate techniques and standardized care can provide favorable patients’ survival.

      Keywords

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