Case report| Volume 32, ISSUE 1, P108-112, April 1936

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Partial gigantism: Overgrowth and asymmetry of bones and skeletal muscle

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      • 1.
        (1) This is a case of “true hypertrophy,” that is, one in which excessive growth of isolated bones of the feet is associated with voluminous lipomatosis of the plantar surface. The hypertrophy of the bone coexists with (a) two congenital vascular tumors; (b) asymmetry of the face; (c) strabismus; and (d) anomaly of the genital organs.
      • 2.
        (2) The occurrence of hypertrophy of the toes is rare; it is even more exceptional that this malformation is combined with other congenital defects.
      • 3.
        (3) The statistics show that hypertrophy of the toes is more frequent in males than in females.
      • 4.
        (4) The operative findings revealed the presence of additional arteries in the areolar tissue of the hypertrophied toes, satisfying the augmented requirement of blood supply in the segment.
      • 5.
        (5) The pathologic report of the involved bone demonstrated the presence of osteoporosis, fatty degeneration of bone marrow and active periosteal bone formation. This corresponds to Wieland's observations. The latter stated, contrary to what was taught by Caubet and Mercade, that hypertrophy of the toe is not a mere quantitative enlargement of the bone, because it presents histologic changes connected with hyperplastic and regressive processes.
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