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Background
As more children survive childhood cancers, the population at risk for second malignant
tumors increases. The development of melanoma as a second malignant tumor is not well
described.
Methods
The M.D. Anderson Cancer Center's 50-year experience with patients who developed melanoma
after treatment of a childhood cancer was retrospectively reviewed.
Results
One hundred seventy-two patients with a second malignancy were identified; 11 patients
had melanoma as a second malignancy. The most common first malignancies were Hodgkin's
disease, brain tumors, and retinoblastomas. Melanoma developed in an irradiated field
in 4 patients. Six patients had lymphatic or distant metastasis at diagnosis. Five
of 11 patients died of melanoma.
Conclusions
Factors contributing to melanoma as a second malignancy may include genetic factors
and the effects of chemotherapy and radiation. Survivors of childhood malignancy should
be considered at risk for developing melanoma, and suspicious pigmented lesions should
be carefully evaluated.
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Article info
Footnotes
**Presented at the 48th Annual Meeting of the Southwestern Surgical Congress, Scottsdale, Arizona, April 28–May 1, 1996.
Identification
Copyright
© 1996 Excerpta Medica, Inc. All rights reserved. Published by Elsevier Inc.
