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Background
Interleukin-6 (IL-6), interleukin-8 (IL-8), and adhesion molecules have been implicated
as mediators in neutrophil (PMN) and endothelial cell (EC) interactions leading to
postinjury multiple organ failure (MOF). Our hypothesis was that circulating levels
of IL-6, IL-8, and soluble intercellular adhesion molecule-1 (s-ICAM-1) would discriminate
patients at risk for postinjury MOF.
Methods
Serial plasma levels of IL-6, IL-8, and sICAM-1 were measured in 27 high-risk trauma
patients.
Results
The IL-6 and IL-8 levels were significantly elevated in MOF patients compared with
non-MOF patients at 12 and 36 hours postinjury. The IL-6 level was also elevated at
84 and 132 hours, and IL-8 at 84 hours. The sICAM-1 level did not become elevated
in MOF patients until 132 hours postinjury.
Conclusion
Interleukin-6 and IL-8 are elevated early after trauma and discriminate patients who
will develop MOF. Late elevation of sICAM-1 likely results from PMN cytotoxicity leading
to EC injury or inflammation.
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Article info
Footnotes
**Presented at the 48th Annual Meeting of the Southwestern Surgical Congress, Scottsdale, Arizona, April 28–May 1, 1996.
1Supported in part by National Institutes of Health grants P50GM49222-01 and T32GM08315-03.
Identification
Copyright
© 1996 Excerpta Medica, Inc. All rights reserved. Published by Elsevier Inc.
