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Scientific Papers| Volume 176, ISSUE 6, P612-617, December 1998

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Resuscitation of the injured patient with polymerized stroma-free hemoglobin does not produce systemic or pulmonary hypertension

  • Jeffrey L Johnson
    Affiliations
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Northfield Laboratories (GAH), Evanston, Illinois, USA
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  • Ernest E Moore
    Correspondence
    Requests for reprints should be addressed to Ernest E. Moore, MD, Chief, Department of Surgery, Denver Health Medical Center, 777 Bannock Street, Denver, Colorado 80204
    Affiliations
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Northfield Laboratories (GAH), Evanston, Illinois, USA
    Search for articles by this author
  • Patrick J Offner
    Affiliations
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Northfield Laboratories (GAH), Evanston, Illinois, USA
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  • James B Haenel
    Affiliations
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Northfield Laboratories (GAH), Evanston, Illinois, USA
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  • George A Hides
    Affiliations
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Northfield Laboratories (GAH), Evanston, Illinois, USA
    Search for articles by this author
  • Douglas Y Tamura
    Affiliations
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Northfield Laboratories (GAH), Evanston, Illinois, USA
    Search for articles by this author

      Abstract

      Background: Hemoglobin-based blood substitutes appear poised to deliver the promise of a universally compatible, disease-free alternative to banked blood. However, vasoconstriction following administration of tetrameric hemoglobins has been problematic, likely because of nitric oxide binding. Polymerized hemoglobin is effectively excluded from the abluminal space because of its size, and is thus less likely to perturb vasorelaxation. We therefore hypothesized that hemodynamic responses would be no different in injured patients receiving polymerized hemoglobin versus banked blood.
      Methods: Injured patients requiring urgent transfusion were randomized to receive either polymerized hemoglobin or banked blood. Systemic arterial pressure, pulmonary arterial pressure, cardiac index, pulmonary capillary wedge pressure, systemic vascular resistance, and pulmonary vascular resistance were measured serially.
      Results: There was no difference in any of the measured hemodynamic parameters between patients resuscitated with polymerized hemoglobin versus blood.
      Conclusions: Polymerized hemoglobin given in large doses to injured patients lacks the vasoconstrictive effects reported in the use of other hemoglobin-based blood substitutes. This supports the continued investigation of polymerized hemoglobin in injured patients requiring urgent transfusion.
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